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Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels


Le Duc Dat, Nguyen Thi Minh Tu, Ngo Viet Duc, Bui Thi Thuy Luyen, Chu Thi Thanh Huyen, Hyun Jae Jang, Dang Thi Thu, Tran Thu Huong, Le Huyen Tram, Nguyen Van Thong, Nguyen Duc Hung, Young Ho Kim, Nguyen Phuong Thao

Source title: 
Carbohydrate Research, 484: 107778, 2019 (ISI)
Academic year of acceptance: 

A phytochemical investigation for the constituents of the stems of Millettia dielsiana Harms ex Diels resulted in the isolation of a new isoflavone glycoside, mildiside A (1), and 14 known compounds (215). Their chemical structures were determined using a combination of IR, NMR, MS, and optical rotation analysis, as well as comparison with the literature data. The ethanolic (EtOH) extract and several isolated compounds exert the inflammatory effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells.