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Megastigmane and abscisic acid glycosides from the leaves of Laurus nobilis L


Le Duc Dat, Ngo Viet Duc, Bui Thi Thuy Luyen, Ha Van Oanh, Hyun Jae Jang, Tran Thu Huong, Young Ho Kim, Nguyen Phuong Thao

Source title: 
Phytochemistry Letters, 33: 1-5, 2019 (ISI)
Academic year of acceptance: 

Two new megastigmane glycosides, laurusides E-F (1 and 3) and three known ones (2, 5, and 7), together with a new abscisic acid glycoside, lauruside G (4) and a known one (6), were isolated from a methanolic extract of Laurus nobilis L. leaves using various chromatographic techniques. The structures of these compounds were fully characterized using a combination of spectroscopic techniques including multinuclear and multidimensional NMR and mass spectrometry. All of the isolates were evaluated for their inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 cells.