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Application of exact continuum size-dependent theory for stability and frequency analysis of a curved cantilevered microtubule by considering viscoelastic properties

Authors: 

Ali Shariati, Mostafa Habibi, Abdelouahed Tounsi, Hamed Safarpour, Maryam Safa

Source title: 
Engineering with Computers, 2020 (ISI)
Academic year of acceptance: 
2020-2021
Abstract: 

The stability analysis of cantilevered curved microtubules in axons regarding various size elements and using the generalized differential quadrature method for solving equations is reported. The impacts of covering MAP Tau proteins along with cytoplasm are taken into account as the elastic medium. Curved cylindrical nanoshell considering thick wall is used to model the microtubules. The factor of length scale (l/R = 0.2) used in modified couple stress theory would result in more accuracy when it comes to comparison with experiments, while alternative theories presented in this paper provide less precise outcomes. Due to the reported precise results, at the lower value of the time-dependent viscoelastic factor (τs)τs) by rising the size-dependent factor, the frequency response of the cantilever microtubule increases and this relation between the size-dependent parameter and the structure’s natural frequency is changed from direct to indirect for the higher amount of the time-based viscoelastic factor that scientists should attend to this matter when it comes to the microtubule. Furthermore, physical neighboring situations in a cell will be prominent in microtubules’ dynamic stability responses, such as membrane and cell-matrix. Since microtubules are likely to be applied as biosensors, this feature could be employed to disclose virulent tumors.