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A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity


Le Huyen Tram, Tran Thu Huong, Le Thi Thuy, Nguyen Van Thong, Nguyen Tuan Anh, Nguyen Hoang Minh, Tran Thu Ha, Dao Anh Dung, Nguyen Phuong Thao, Phuong Thien Thuong, Duc Dat Le, Nguyen Dinh Hiep, Hee Jae Shin

Source title: 
Natural Product Research, 2021 (ISI)
Academic year of acceptance: 

A series of schiartane C29 nortriterpenoids with 5/5/7/6/5 membered consecutive rings (15) with an unique schinortriterpenoid skeleton including a new, kadcoccilactone V (1), together with four known ones (25) and three known triterpenoids (68) were identified from stems of Kadsura coccinea (Lem.) A. C. Smith. The structures of 1 and known compounds were elucidated by interpretation of 1D and 2D NMR, and HR-ESI-MS data as well as comparing those data in the literature. All the isolated compounds were examined for cytotoxic effects against six human cancer cell lines [(HCT-15 (colon), NUGC-3 (stomach), NCI-H23 (lung), ACHN (renal), PC-3 (prostate), and MDA-MB-231 (breast)]. Among them, compound 6 showed potent cytotoxicity against NCI-H23 (GI50 1.28 µM) and NUGC-3 (GI50 1.28 µM), and significantly inhibited on PC-3, MDA-MB-231, ACHN, HCT-15 with GI50 values around 2.33 to 2.67 µM.

Graphical abstract