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Secondary metabolites from Valeriana jatamansi with their anti-inflammatory activity


Le Huyen Tram, Nguyen Van Thong, Le Thi Thuy, Nguyen Tuan Anh, Nguyen Hoang Minh, Tran Thi Minh, Nguyen Thi Hong Phuong, Tran Thu Ha, Thi Minh Nguyet Nguyen, Duc Dat Le, Nguyen Dinh Hiep, Jong-Tae Park, Truong Thi To Chinh, Tran Thu Huong, Mina Lee

Source title: 
Natural Product Research, 2021 (ISI)
Academic year of acceptance: 

Valeriana jatamansi is hired as multiple remedies for treatment of insomnia, blood and circulatory disorders, asthma, dry cough, jaundice, seminal weakness, cardiac debility, and skin diseases in Vietnam. Our research discovered the phytochemical investigation of constituents from this herbal medicine resulted in the isolation of two new compounds (jatamansides A (4) and B (7)) together with 16 known ones from the whole plant. Their structures were established by using spectroscopic techniques (multinuclear and multidimensional nuclear magnetic resonance, infrared, ultraviolet-visible), mass spectrometry, hydrolysis analysis, or comparing their NMR data to those reported in the literature. In addition, all the isolates were evaluated for their inhibitory effect against TNF-α production in LPS-stimulated on RAW264.7 cells with significant inhibition.